Women are genetically more prone to depression than men, according to a new study by Australian researchers.
Scientists from the QIMR Berghofer Medical Research Institute in Queensland discovered twice as many genetic “flags” or warning signs for depression in women compared to men.
The global study, published in Nature Communications, analysed the DNA of 200,000 people diagnosed with depression, with women making up two-thirds of the participants. It identified around 7,000 DNA changes linked to depression in both sexes and a further 6,000 unique to females.
Researchers also found that women were more likely to experience symptoms such as daytime drowsiness, increased appetite, and weight gain, while men tended to show signs like substance abuse, anger, and risk-taking behaviour.
Lead researcher Jodi Thomas said the findings could pave the way for more gender-specific research and treatment approaches.
“Unpacking the shared and unique genetic factors in males and females gives us a clearer picture of what causes depression – and opens the door to more personalised treatments,” she explained.
The study highlights the importance of considering sex-specific genetic influences when studying depression and related health conditions.
